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World Health Organization Issues New Guidelines Suggesting Use of Prophylactic Negative Pressure Wound Therapy to Reduce the Risk of Surgical Site Infections (SSIs)

Guidelines underscore the importance of negative pressure wound therapy in preventing costly SSI complications

November 04, 2016 | SAN ANTONIO
The World Health Organization (WHO) announced new global guidelines concerning surgical site infections (SSIs) – a significant contributor to unnecessary costs associated with patient complications. In its announcement, the agency suggests use of prophylactic negative pressure wound therapy (pNPWT, or closed incision negative pressure therapy [ciNPT]) over conventional wound dressings on primarily closed surgical incisions in high-risk wounds for the prevention of SSIs. In establishing these guidelines, WHO has recognized the significant burden SSIs place on global healthcare systems, both in terms of financial implications and patient outcomes, and has taken steps to reduce these burdens by suggesting the use of pNPWT/ciNPT on surgical incisions.

To develop the guidelines, WHO commissioned a systematic review and meta-analysis of 21 studies including both randomized controlled trials and observational studies, of which 76 percent utilized ACELITY™ negative pressure therapy products. The conclusions, published in the September issue of Medicine, found that pNPWT significantly reduced the risk of SSIs compared to traditional dry gauze dressings.
 
“The new WHO guidelines build upon a significant body of evidence that illustrates the impact negative pressure therapy can have in reducing the incidence of surgical site infections,” said Ron Silverman, M.D., FACS, chief medical officer of Acelity. “We developed PREVENA™ Therapy as the first disposable powered negative pressure system designed specifically for the management of closed surgical incisions six years ago, building off our demonstrated expertise in this space. Acelity brought the gold standard NPWT technology, V.A.C.® Therapy, to market in 1995 and, since then, V.A.C.® Therapy has been used to treat more than 10 million open wounds worldwide. We continue to build upon that track record by expanding our portfolio to improve patient care and address the needs of a changing healthcare system.”

Surgical site infections place a large burden on patients and global healthcare systems, particularly in the U.S., as they are associated with productivity loss, extended hospital stays, increased health care provider visits and greater financial costs. According to one study published in JAMA Internal Medicine, the average cost of an SSI in 2012 was estimated to be $20,785 per patient.  Further evidence on the benefits of ciNPT was published in the August 2016 issue of International Wound Journal, noting SSIs are prevalent in up to 60 percent of inpatient surgical procedures in industrialized countries.  There is a clear need to address the burden of SSIs on patients and the healthcare system. Closed incision negative pressure therapy has demonstrated the ability to reduce the rates of SSIs, and surgeons from various disciplines have found that ciNPT is associated with positive clinical outcomes compared to standard post-operative dressings.  
 
PREVENA™ Therapy Systems
The PREVENA™ Incision Management System is the first powered negative pressure product designed specifically for the management of closed surgical incisions that continue to drain following sutured or stapled closure. It covers and protects the incision from external contamination, while negative pressure removes fluid and infectious material from the surgical incision, helping clinicians effectively manage surgical incisions. The new PREVENA PLUS™ System offers the proven effectiveness of ciNPT with a customizable dressing designed for linear, non-linear, and intersecting incisions up to 90cm in length, allowing for the treatment of a variety of different incision types.

About Acelity
Acelity L.P. Inc. and its subsidiaries are a global advanced wound care and regenerative medicine company created by uniting the strengths of three companies, Kinetic Concepts, Inc., LifeCell Corporation and Systagenix Wound Management, Limited. Available in more than 80 countries, the innovative and complementary ACELITY™ product portfolio delivers value through solutions that speed healing and lead the industry in quality, safety and customer experience. Headquartered in San Antonio, Texas, Acelity employs more than 5,800 people around the world.
 

For more information, contact:

Kathryn Skeen
Corporate Communications
Phone: +1-210-882-2067
Email: kathryn.skeen@acelity.com
 
Caleb Moore
Investor Relations
Phone: +1-210-255-6433
Email: caleb.moore@acelity.com
 

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