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PROMOGRAN™ Matrix Wound Dressing

The information on this page is intended for healthcare professionals. Patient-specific information is available in the “Patients” section of this site. Patients should consult a healthcare professional regarding specific medical conditions and treatments.
PROMOGRAN™ Matrix Wound Dressing
PROMOGRAN™ Matrix Wound Dressing

A Clinically Proven Combination

PROMOGRAN™ Matrix Wound Dressing is comprised of a sterile, freeze dried composite of 45% oxidized regenerated cellulose (ORC) and 55% collagen.
 
Optimum Wound Environment
PROMOGRAN™ Matrix Wound Dressing maintains a physiologically moist microenvironment at the wound surface. This environment is conducive to granulation tissue formation, epithelization and rapid wound healing.

Overview

Clinically Proven

PROMOGRAN™ Matrix Wound Dressing COLLAGEN & ORC The efficacy supported by a body of clinical evidence, including RCT data1

Economic Value

With PROMOGRAN™ Matrix Wound Dressing and PROMOGRAN PRISMA™ Matrix. Summary of the Supplement to Ostomy Wound Management, November 2010, Vol. 56, Issue 11A.Read the PROMOGRAN™ Matrix Economic Value Brochure: 
Economic Value Brochure
 

Acelity™ Advanced Wound Dressings Advanced Dressing Technology

PROMOGRAN™ Matrix Family, the only dressings with collagen and Oxidized Regenerated Cellulose (ORC).

System Components & Accessories

How it Works

  • About
  • Specifications
  • Materials For Download

About

Maintains an optimum wound-healing environment

In the presence of exudate, PROMOGRAN™ Matrix transforms into a soft, conformable, biodegradable gel. This allows contact with all areas of the wound.

PROMOGRAN™ Matrix maintains a physiologically moist microenvironment at the wound surface. This is conducive to granulation tissue formation, epithelialization and rapid wound healing.

Studies have shown that the moist wound environment, which PROMOGRAN™ Matrix helps optimize, promotes healing1.
  • Optimum wound environment
  • Clinically proven
 
PROMOGRAN™ Matrix Wound Dressing
PROMOGRAN™ Matrix Wound Dressing

Specifications

Product description
PROMOGRAN™ Matrix Wound Dressing is an advanced wound care device comprised of a sterile, freeze dried composite of 45% oxidized regenerated cellulose (ORC) and 55% collagen. In the presence of exudate the PROMOGRAN™ Matrix transforms into a soft, conformable, biodegradable gel, and thus allows contact with all areas of the wound.
 
PROMOGRAN™ Matrix maintains a physiologically moist microenvironment at the wound surface. This environment is conducive to granulation tissue formation, epithelialization and rapid wound healing. PROMOGRAN™ Matrix is a primary dressing that can be cut to fit wound with sterile scissors and used in combination with either a semi-occlusive or non-occlusive secondary dressing. Prior to application in dry wounds saline solution should be used to hydrate PROMOGRAN™ Matrix.

Materials For Download

Product Information

Indications & Applications

Indications & Applications

  • Indications
  • Applications

Indications for Use

PROMOGRAN™ Matrix is intended for the management of exuding wounds including:
  • Diabetic ulcers
  • Venous ulcers
  • Pressure injuries
  • Ulcers caused by mixed vascular etiologies
  • Full-thickness & partial thickness wounds
  • Donor sites and other bleeding surface wounds
  • Abrasions
  • Traumatic wounds healing by secondary intention
  • Dehisced surgical wounds
 
PROMOGRAN™ Matrix may be used under compression therapy with healthcare professional supervision. Precautions PROMOGRAN™ Matrix may be used when visible signs of infection are present in the wound area only when proper medical treatment addresses the underlying cause. Contraindications PROMOGRAN™ Matrix is not indicated for wounds with active vasculitis, third-degree burns, or patients with known sensitivity to ORC or collagen.
 
Before use, physicians should review complete risk information and essential prescribing information which can be found in the Product Instructions for Use. To order any of the products listed below, please call 1-800-275-4524.
 

Applications

Wound Bed Preparation
Prepare wound bed per your standard wound care protocol and debride when necessary. Wound bed should be clear of any visual signs of infection.
 
Application
  • For optimal effect, apply PROMOGRAN™ Matrix directly to the whole wound bed.
  • For a wound with low or no exudate apply PROMOGRAN™ Matrix and hydrate with saline solution. This will initiate the transformation of the PROMOGRAN® Dressing into a gel matrix.
  • After hydration, through exposure to wound exudate or saline, the PROMOGRAN™ Matrix gel will intimately come into contact with the wound surface.
  • The biodegradable PROMOGRAN™ gel matrix is naturally absorbed into the body over time.
  • In order to maintain a moist wound healing environment PROMOGRAN™ Matrix must be covered with a semi-occlusive dressing (e.g. BIOCLUSIVE™ Plus Transparent Film Dressing, TIELLE™ Hydropolymer Foam Dressings or TIELLE™ Plus Hydropolymer Adhesive Dressing) or a non-occlusive secondary dressing and fixed to the skin with a non-irritating tape.
  • After initial application, reapply PROMOGRAN™ Matrix to the wound up to every 72 hours depending upon the amount of exudate. It is not necessary to remove any residual PROMOGRAN™ Matrix during dressing changes.
 
 

Instructions for Use

Clinical Solutions for

Evidence & Outcomes

The efficacy of PROMOGRAN™ Matrix is supported by clinical evidence, including 1 published RCT1. Acelity Clinical Evidence is a resource for healthcare professionals to explore preclinical, clinical, and review articles discussing the use of KCI and Systagenix products. Use our powerful search tool to customize your view of the Acelity product evidence.

For questions or to request published literature contact Medical Information

Clinical Evidence

Additional summary of evidence and outcomes.

Evidence & Outcomes

Evidence & Outcomes

Title Study Type Date Authors
Mechanism of action of PROMOGRAN, a protease modulating matrix, for the treatment of diabetic foot ulcers
2002
Cullen B et al.
Cost-effectiveness of treating deep diabetic foot ulcers with Promogran in four European countries
2002
Ghatnekar O et al.
Randomized controlled trial on collagen/oxidized regenerated cellulose/silver treatment.
2013
Gottrup F et al.
Synergistic action of protease-modulating matrix and autologous growth factors in healing of diabetic foot ulcers. A prospective randomized trial.
2007
Kakagia DD et al.
Expression of matrix metalloproteinases and growth factors in diabetic foot wounds treated with a protease absorbent dressing.
2006
Lobmann R et al.
A randomized, controlled trial of Promogran (a collagen/oxidized regenerated cellulose dressing) vs standard treatment in the management of diabetic foot ulcers.
2002
Veves A et al.
Wound conditioning of a deep tissue defect including exposed bone after tumour excision using PROMOGRAN* Matrix, a protease-modulating matrix.
2005
Tausche AK et al.
The healing properties of Promogran in venous leg ulcers.
2002
Vin F et al.
Some effects of a topical collagen-based matrix on the microcirculation and wound healing in patients with chronic venous leg ulcers: preliminary observations
2005
Wollina U et al.
Use of a protease-modulating matix in the treatment of pressure sores
2005
Nisi et al.
Randomized comparative trial of a collagen/oxidized regenerated cellulose dressing in the treatment of neuropathic diabetic foot ulcers
2007
Lazaro-Martinez et al.
Effect of oxidized regenerated cellulose/collagen matrix on proteases in wound exudate of patients with diabetic foot ulcers
2011
Ulrich et al.
Effect of oxidised regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration
2008
Smeets et al.
Prospective and randomised evaluation of the protease-modulating effect of oxidised regenerated cellulose /collagen matrix treatment in pressure sore ulcers
2015
Smeets et al.
Expression of Matric-Metalloproteases in the Fluid of Chronic Diabetic Foot Wounds Treated with a Protease Absorbent Dressing
2011
Motzkau et al.
The role of oxidized regenerated cellulose / collagen in wound repair: effects in vitro on fibroblast biology and in vivo in a model of compromised healing
2002
Hart et al.
Modulation of the chronic wound environment; an in vitro evaluation of advanced wound therapies
2007
Cullen et al.
Collagen ORC rebalances the wound environment
2003
Cullen et al.
The benefits of oxidized regenerated cellulose (ORC) for wound healing
2010
Cullen et al.

Ordering

To order any of the products listed below, call 1-800-275-4524.
 
If you would like to request a free sample click the contact button on the right.

Contact Us

Product Codes

PROMOGRAN™ Matrix Wound Dressing

Product Product Code Ordering Option
PROMOGRAN™ Matrix Wound Dressing
4.34 sq.in Hexagon
PG004
10 eaches/CT 4 CT/BX/40/A6021
PROMOGRAN™ Matrix Wound Dressing
19.1 sq.in Hexagon
PG019
10 eaches/CT 4 CT/BX/40/A6022
Want to learn more? Please call +1 800-275-4524 or click here.
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